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Despite sharing no homology with ghrelin, GHRP-2 and GHRP-6 appear to reliably activate the GHS-R1a and also stimulate hGH release from the pituitary cells
However, GLP-1's very short half-life, arising from cleavage by the enzyme dipeptidyl peptidase 4 (DPP-4) and glomerular filtration by the kidneys, presented challenges for clinical use
Insulin resistance and alzheimer's disease pathogenesis: potential mechanisms and implications for treatment
Funding This work was supported by a Research Start-up Grant awarded to SKK
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