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Against a background of IV biosimilar competition post-2028 that could erode IV pembrolizumab revenues by 60 to 80 percent over three years, the subcutaneous franchise represents the primary IP-protected revenue stream for the Keytruda franchise in the 2028 to 2035 period

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Warfarin interaction is clinically relevant because GLP-1-induced changes in gastric emptying can alter absorption of narrow-therapeutic-index drugs, and QT prolongation matters because of the cardiac side-effect profile of some weight-loss adjuncts

It enhances glucose-dependent insulin secretion, inhibits glucagon release, slows gastric emptying, and suppresses appetite via central nervous system pathways (Milder et al