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While more research is unquestionably needed, a study looking at weekly semaglutide use showed improved weight and knee pain in people with obesity and knee osteoarthritis (with moderate to severe pain)
However, prolonged oral administration for 6 weeks does not promote growth and abolishes the GH stimulatory effect of MK-677, potentially resulting from increased expression of SST in the hypothalamus
(Hershman 2013) Two-year follow-up confirmed persistent and worsening CIPN in the LC group without recovery, suggesting long-term harm
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