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Such limitations prompted the development of second-generation medicines capable of sustaining stable drug concentrations with reduced dose frequency, hence enhancing both effectiveness and tolerance characteristics
This is particularly relevant for small, frequent doses from large vials
Mild side effects noted in clinical trials have included bloating or mild cramps, gas and/ or loose stools, potential weight gain, and flushed skin
CHAC1 degradation of glutathione enhances cystine-starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway
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