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The study focused on two genetic variants that affect the enzyme peptidyl-glycine alpha-amidating monooxygenase (PAM)
Tirzepatide is a dual GIP and GLP-1 receptor agonist licensed in the UK for type 2 diabetes mellitus and weight management
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The results showed high heterogeneity of weight loss from the baseline weight between individuals even at the highest dose of tirzepatide 38.4 to 9.0 kg and mean 22.1 kg
Mitochondrial dysfunction plays a key role in the occurrence and development of skeletal muscle atrophy mainly through the molecular mechanism mediated by this signaling axis [35]
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