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[4] [6] This relationship is bidirectional and complex, involving: Inflammatory pathways that affect both metabolic and mental health Hormonal dysregulation impacting mood and stress responses Psychosocial factors including stigma, body image concerns, and chronic disease burden Lifestyle factors such as reduced physical activity and poor sleep quality When GLP-1 medications improve glycaemic control, facilitate weight loss, and enhance overall metabolic health, patients may experience secondary improvements in psychological wellbeing

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Serati AR, Motamedi MR, Emami S et al (2010) L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms