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Methods: Male Wistar rats were repeatedly administered with the AT 1 -R blocker candesartan (CAND) and AMPH

The most parsimonious hypothesis is simply that this is a case of a viral protease targeting a cellular gene for cleavage, for which there are abundant precedents, including the proposed M pro targeting of TRMT1 and HDAC2 ( Functional Effects of M PRO in Transfected Cells are Consistent With GPX1 Knockdown As detailed above, the original 2003 SCoV M pro has essentially identical substrate sequence specificity as that of SCoV2

Addolorato G, Parente A, de Lorenzi, et al

This reprograms SMA CAFs into collagen-III inflammatory CAFs (iCAFs), forming a fibrotic niche that supports CD44 CSCs, thereby fueling chemoresistance