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Because insulin resistance in PCOS is a whole-body phenomenon expressed most strongly in skeletal muscle, liver, and adipose tissue, and retatrutides three signals converge on exactly those tissues indirectly, by driving large reductions in body weight and ectopic (especially hepatic) fat, and possibly directly, through incretin effects on the pancreatic islet and on adipose biology

I havent had any nausea or anything and have completely had a decrease in appetite and cravings

Hims & Hers's buzzy ad campaigns marketed their versions of these drugs as an effort to democratize weight loss, in direct opposition to big pharmaceutical companies' high-priced solutions

The most common side effects are gastrointestinal: nausea, diarrhea, constipation, and reduced appetite