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Vitamin C in extremely high doses (more than 1000 mg taken with a b12 supplement) may reduce b12 absorption when taken together
[2] This whole process may be regulated by a negative feedback mechanism, which may nullify any ancillary impacts of excess GH production
10.1016/s0928-4257(97)89474-0 120 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997a)
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