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In addition, if you're one the millions of Americans taking proton pump inhibitors, known as PPI's, that suppress stomach acid for conditions like acid reflux, you're going to be prone to Vitamin B12 deficiency

There may be some amount of discomfort during the administration which is usually tolerable

Spectrochim Acta Part A Mol Biomol Spectrosc 308:123671 Schmidt R, Logan MG, Patty S, Ferracane JL, Pfeifer CS, Kendall AJ (2023) Thiol quantification using colorimetric thiol-disulfide exchange in nonaqueous solvents

Vitamins and minerals sometimes taken orally, and sometimes administered via IV or as a vitamin injection can help