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MT1 as afamelanotide is delivered as a subcutaneous implant (16 mg per implant, replaced every 60 days in clinical use), which is a fundamentally different pharmacokinetic profile than the repeated subcutaneous injections used in MT2 self-administration
In overweight or obese patients without diabetes mellitus, patients treated with GLP-1 RAs had significantly reduced major adverse cardiovascular events, all-cause death, myocardial infarction, and revascularization when compared with placebo [36] [37] [38]
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