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Contact your GP or diabetes specialist nurse if you experience: Persistent or severe nausea and vomiting that prevents adequate fluid or food intake Signs of dehydration , including reduced urination, dark urine, dizziness, or dry mouth Severe abdominal pain , particularly if constant or worsening Vomiting of undigested food several hours after eating Unexplained weight loss beyond expected therapeutic effects Blood in vomit or black, tarry stools Difficulty swallowing or sensation of food getting stuck Seek immediate medical attention (A&E, NHS 111, or call 999) if: You experience severe, unrelenting abdominal pain You have persistent vomiting preventing any fluid intake for more than 24 hours You develop signs of severe dehydration or altered consciousness You experience symptoms suggestive of pancreatitis (severe upper abdominal pain radiating to the back) For patients with diabetes, erratic blood glucose control despite usual management may indicate impaired gastric emptying affecting carbohydrate absorption and insulin timing

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Its levels decline with age, corr elating with slower wound heal ing, thinning hair, and reduce d skin elasticity