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TB-500 also influences dermal papilla cells to enhance their production of growth factors including IGF-1, VEGF, and FGF-7 that support hair matrix cell proliferation and shaft formation
It is known that GSSG is reduced by glutathione reductase (GR) to replenish the GSH pool and GR activity and expression of the coding genes are activated by SA (Kirly et al., 2002
Despite the fact that the ferroptosis triggered by these pathogens has not been validated in skin tissues, these studies bring new insights into the research of their respective pathogenesis and therapeutic targets (Figure 4)
