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This might explain the common x axis intercept in LineweaverBurk plots 11,17,18 , which resemble a non-competitive inhibition pattern with identical dissociation constants for the inhibitor and substrate 52
What happens is the inflammatory process inside the plaque, which is especially driven by the seed oils oxidizing in there and going rancid
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18 A hallmark of MDR is the dysregulation of intracellular drug availability, primarily through impaired drug uptake and enhanced drug efflux, involving the SLC and ABC transporter families
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