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Control groups received saline injections

Inui et al

8 Findings from current studies of APAP hepatotoxicity seem to favor the mechanism of toxic injury being related to mitochondrial and endoplasmic reticula leading to hepatocyte injury and necrosis

Amongst all treated groups, the highest levels of both ABCA1 and LRP1 (7.96 and 12.7 folds) and the lowest RAGE level (45.32%) were observed in the group receiving the combination therapy as compared to the untreated ICV-STZ rats