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Researchers investigating which fragment of -MSH carried the anti-inflammatory activity narrowed it down to the C-terminal tripeptide the last three amino acids of the molecule: lysine, proline, and valine
Oxidative stress responses clarified the functioning of central principal switches like nuclear factor (NF)-B (NFB) or the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway (Sies, 2015
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