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The role of senescent cells in ageing
In the STEP 3 randomised trial, once weekly semaglutide 2.4 mg used in obese adults without diabetes was associated with 4.9% incidence of gallbladder related disorders (mainly cholelithiasis) compared with 1.5% in the placebo group (1)
Broader clinical trial data suggests that approximately 10% of patients across all indications and doses may discontinue semaglutide due to GI complaints, which is comparable to or slightly higher than other GLP-1 receptor agonists
This leaves the glutamate -carboxyl free and is why glutathione is classified as a tripeptide without a conventional peptide backbone
