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Medications that can enhance the activity of insulin (so-called incretin mimetics) can help to overcome insulin resistance caused by SGAs (and potentially by other psychotropic medications) and essentially lead to weight loss through enhanced fuel efficiency. Metformin, typically dosed up to 1,000 mg twice daily with meals, has increasingly become recognized as a first-line strategy to attenuate weight gain and glycemic dysregulation from SGAs via its ability to reduce insulin resistance

In a 2026 podcast interview, Huberman called retatrutide "the peptide that's going to change everything" and described it as a triple agonist of GLP-1, glucagon, and GIP receptors

Here are situations where staying on semaglutide, or exploring other options, may be more appropriate

I really like how this makes my thinner hair feel after a wash and blow dry