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A study found that a combination of creatine and L-carnitine led to a significant increase in muscle protein synthesis, suggesting a potential synergistic enhancement of muscle protein synthesis and activation of anabolic signalling [7]

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These in vitro results have been further validated in murine models of malaria infection and rheumatoid arthritis, where G6PD-d or inhibition leads to less severe proinflammatory responses to stimulation marked by reduced Th1 and Th17 differentiation, decreased proatherogenic cytokines IL-1, IL-6, IL-12, and TNF, and no impact on IL-10 and TGF (classically Treg-derived) 120,121,122,123,124

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To our knowledge, the present study is the first to examine the effects of l-theaninecaffeine combination on overall cognition using a standardized validated test battery such as the NIH Cognition Toolbox

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