Glutathione depletion has been observed in various liver diseases, including fatty liver disease, viral hepatitis, and cirrhosis
It further regulates genes related to bile acid synthesis in the liver, such as Cyp7a1 , through the intestine-liver axis, ultimately exacerbating systemic metabolic disorder in diabetic mice (Perino et al., 2021)
Access this article Similar content being viewed by others Abbreviations -GCL: -glutamate cysteine ligase GGT: -glutamyl transferase BSO: L-buthionine-(S, R)-sulfoximine GPx: glutathione peroxidase GSH and GSSG: reduced and oxidized glutathione, respectively MAPK: mitogen-activated protein kinase miR: microRNA Nrf2: NF-E2-related factor 2 ROS: reactive oxygen species REFERENCES Scir, A., Cianfruglia, L., Minnelli, C., Bartolini, D., Torquato, P., Principato, G., Galli, F., and Armeni, T
Like glutathione, NAC has low bioavailability