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Yes, rapid improvement in glycemic control with any diabetes medication can occasionally trigger treatment-induced neuropathy of diabetes, which presents as acute painful neuropathy and typically improves over time

This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin, which can cause a deficiency if not supplemented properly

Studies on tendon-to-bone healing show similar benefits

Some people notice improvements in energy, skin clarity, and overall wellness within a few weeks, while deeper cellular benefits and antioxidant support may take several weeks to months