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Mechanistically, this may relate to GHK-Cu's ability to upregulate matrix metalloproteinases (MMP-1, MMP-2), enzymes that can fragment collagen if their activity exceeds the body's ability to rebuild
10,53,54 Recall, 17-estradiol is the most potent steroid hormone produced by the ovaries until menopause (Figure 3)
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It remodels the epigenome and protects DNA: By binding to promoter regions and loosening chromatin structure, Epitalon may restore youthful gene expression patterns, enhance DNA repair, and reduce mutation load, positioning it as a precision gene-expression modulator rather than a blunt genetic tool
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