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In these neurons, the presence of GLP-1 signifies mechanical distension in the gut, signalling the neurons to facilitate increases in gastric pressure which is needed for normal digestion and may explain other gastrointestinal side-effects such as diarrhea

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Photo illustration by Alexander Castro/Rhode Island Current) Are GLP-1 drugs prescribed for weight loss becoming too outsized a line item for continued coverage through the state Medicaid program

Launching oral GLP-1s requires more than extending injectable playbooks