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In COVID-19 patients, an increase in inflammatory cytokines, such as interleukin 6 (IL-6), IL-2, IL-7, IL-10, granulocyte colony-stimulating factor (GCSF), interferon -induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein 1-alpha (MIP1A), and tumor necrosis factor (TNF-), is observed which is called cytokine storm [5]
However, the clinical development of some ultra-potent DNA-intercalators like the pyrrolobenzodiazepine (PBD) dimers has been challenged by significant off-target toxicities, potentially related to their persistent DNA damage and the bystander effect [47]
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From there it quietly shapes identity and interpretation long before it ever appears as a formal diagnosis
