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Retatrutide is a triple agonist acting on GLP-1, GIP, and glucagon receptors, with phase 2 data published in the New England Journal of Medicine (2023) showing substantial weight reduction
But 800 cals with small variation is ok so far, lots of water and coffee
If you have a history of depression or anxiety, keeping your mental health provider informed while on a GLP-1 is sensible
NICE guidance (NG28) recommends considering dose reductions of insulin or sulfonylureas when initiating a GLP-1 receptor agonist to mitigate this risk
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