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Although its physiological role remains unclear, DSIP illustrates several concepts applicable to other brain peptides
The CD4+/CD8+ ratio serves as a key marker of immune system aging, with a shift toward CD8+ dominance often linked to chronic inflammation, reduced pathogen defense, and heightened all-cause mortality risk
Later Phase (weeks 9-12+) Plateau windows scale may stall for 2-3 weeks despite good compliance
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