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Nello studio, la perdita di peso con semaglutide 2,4 mg stata inferiore a quella dimostrata in un altro studio clinico, Step-1, che ha dimostrato una perdita di peso media del 17%, e una persona su tre ha mostrato una perdita di peso del 20%
Overweight and obesity management (NG246): Physical activity and diet NICE
GLP-1RA and DPP-4 inhibitors are useful in the management of patients with T2DM over the spectrum of HbA1c levels, including drug nave patients as well as those treated with other glucose lowering therapies
Preliminary data suggest that GLP-1RAs may be effective in the treatment of hypothalamic obesity, and the presence of GLP-1R in various regions of the hypothalamus and in other regions of the brain explains the potential effectiveness of GLP-1RAs even in cases of hypothalamic damage [16]
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