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The Connectivity Map and Gene Expression Analysis The Broad Institute's development of the Connectivity Map (cMap) database, which contains gene expression profiles of human cell lines treated with thousands of bioactive compounds, allowed Pickart and colleagues to characterize GHK-Cu's genomic influence at a previously impossible scale
centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017
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When one pathway potentially adapts, the others maintain effectiveness
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