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Prokinetic agents like metoclopramide present a theoretical option but should be used cautiously given potential adverse effects (including tardive dyskinesia with use beyond 12 weeks) and the counterintuitive nature of accelerating gastric emptying while using a medication that intentionally slows it
5.3 Exercise regulates exerkines expression Exerkines are bioactive molecules secreted by exercise-stimulated tissues such as skeletal muscle, adipose tissue, liver, brain, and other organs, including myokines, cardiokines, hepatokines, adipokines, neurokines, lactate, and miRNAs
The higher pH protects the peptide from pepsin degradation, which requires acidic conditions
The strongest body-weight meta-analysis found a modest average reduction of about 1.21 kg, with the best dose-response signal near 2,000 mg/day, mostly in adults with overweight or obesity
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