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53 Future Directions and Unanswered Questions Despite recent evidence from clinical trials, key questions remain about the optimal use of GLP-1RAs for HF

We have to admit, the clinical trials look pretty good on the surface

Bowel obstruction Small increases in resting heart rate Thyroid C-cell tumors observed in animal studies Dizziness or lightheadedness Dry mouth or increased thirst Vision changes Dehydration related to excessive vomiting or diarrhea Temporary hair shedding during rapid weight reduction Severe allergic reactions, including swelling of the face or throat or difficulty breathing, require immediate medical attention

Results According to the search results and defined exclusion criteria, a total of 51 studies were found suitable for analysis (Supplementary information S1)