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This upregulation facilitates the binding of ICAM-1 to the integrin CD11/CD18 complex on neutrophils, thereby enhancing leukocyte adhesion [173, 181]
They are more commonly associated with iron deficiency anemia but have also been linked to vitamin C deficiency ( Red spots or vertical lines in the nail bed, known as splinter hemorrhage, may also appear during vitamin C deficiency due to weakened blood vessels that rupture easily
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