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But when severe hypoxia occurs, the number of red blood cells increases, and the compensatory significance of the above changes into harmful effects, causing an increase in blood viscosity, a decrease in cell deformability, and difficulty for cells to pass through microvessels, further leading to tissue hypoxia, a vicious cycle, and ultimately the occurrence of HAPC

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doi:10.1021/bi9605245

Despite these caveats, an increase in brain lactate in ME/CFS patients has been previously reported in 3T MRS investigations, in the ventricle CSF rather than in the brain tissue [14,15,16,17], and also in the ACC, similar to our study (the voxel in this study was placed in the area covering adjacent parts of our voxels) [13]