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Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]
But each time a cell divides, these protective caps erode slightly, like the tips of shoelaces fraying over time
Reduced endothelial activation and leukocyte adhesion are particularly relevant to early vascular dysfunction
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