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These transcribed sequences mainly include lncRNAs, miRNAs, and circRNAs, which generally do not encode proteins but play regulatory roles at the transcriptional or post-transcriptional level (77)
To test the involvement of NRF2, we bred the Gclc f/f mouse strain with the Nrf2 f/f mouse strain 57,58 and induced a liver-specific double deletion with the AAV-TBG-Cre virus (hereafter referred to as L-DKO) (Fig
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