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high consumption of processed and refined food, with lack of dairy and meat-based food in diet, excessive consumption of alcohol, impaired absorption from the gastrointestinal tract or impaired storage and use by liver (1)

Some supplements have the potential of raising the bodys glutathione levels: Vitamin E studies show that vitamin E levels are directly linked to glutathione levels, and supplementation of vitamin E significantly increases glutathione while also fighting against lipid peroxidation

This is a general pharmacokinetic principle based on the protein stability characteristics of each formulation