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"It's been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver," said neurobiologist Makoto Fukuda from Baylor College of Medicine in the US when the research was published
It is worth being precise here: engaging three pathways simultaneously is a rational design hypothesis, but how those combined effects translate into durable, safe clinical outcomes in patients is exactly what the ongoing trials are intended to determine
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Average weight loss also favored tirzepatide at all evaluated time points
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