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however, metformin is associated with failure in glycaemic control in approximately half of adolescents 13 , and insulin is associated with hypoglycaemia and weight gain 4,5

We found that elective histamine 3 receptor (H3R) signaling in the intestine was critical for this effect, as systemic and intrathecal application did not show effects

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Larger, well-designed randomized controlled trials are warranted to clarify efficacy, confirm findings in adequately powered addiction-focused studies, identify responsive subgroups, and establish appropriate treatment protocols