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In trained immunity, primary human CD14+ monocytes exposed with -glucan (activating the classic Dectin-1 trained immunity pathway) triggers a sustained upregulation of mitochondrial glutaminolysis, causing the specific accumulation of the TCA cycle intermediate fumarate inside the mitochondria
10.1016/j.ecoenv.2025.118142 299 LuoN.ZhuW.LiX.FuM.PengX.YangF.et al
In people with preexisting conditions like chronic kidney disease or liver cirrhosis, high-dose IV infusion may place additional stress on these organs
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