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This increases and then depletes your glutathione levels

In prostate cancer, emodin treatment causes necroptosis-mediated cell death by stimulating the expression of HSP90 and PGAM5, a central modulator of mitochondrial fission, leading to the massive generation of ROS and necroptosis (Zhou et al., 2023)

Additionally, the tricarboxylic acid (TCA) cycle is used by M1 macrophages to produce succinate, which stabilizes hypoxia-inducible factor 1 (HIF-1), and citrate, which serves as a precursor for fatty acid synthesis and the antimicrobial metabolite itaconate (112, 113)

Due to its well-characterised molecular structure, reproducible analytical profile and broad scientific relevance, glutathione remains an important research material for biochemical, molecular and cellular investigations