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Phase 1: Reduce the overgrowth We use herbal antimicrobials as our first-line treatment
formulated a curcumin nanoparticle-loaded hydrogel that facilitated reepithelization and dermal junction reconfiguration, significantly increasing collagen deposition and VEGF and AQP3 production, thereby promoting effective wound healing (Kamar et al
Furthermore, in the presence of ischemia and hypoxia, endothelial cells elevate the synthesis of ROS, and elevated levels of ROS inflict additional harm on endothelial cells [86]
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