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The clinical trial protocol provides a tested framework that balances efficacy with manageable side effects
Poor sleep impairs healing, increases pain sensitivity, and prolongs recovery
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First, endothelial dysfunction develops through TNF-/IL-1-mediated eNOS suppression, ROS-mediated NO depletion, ET-1 and angiotensin II activation, RhoA/ROCK signaling, AGERAGE/NF-B amplification, and sympathetic catecholamine-driven vasoconstriction (3, 157159)
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