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Public literature is concentrated in Phase 12 trial reports and preclinical pharmacology
In preclinical models, BPC157 has been shown to modulate expression of key inflammatory mediators by downregulating proinflammatory transcription factors such as NFB and AP1 while upregulating antiinflammatory genes linked to IL10 signaling, thereby shifting the balance toward resolution of inflammation in chronically injured tissues (24,25)
Berberine Attenuates Experimental Autoimmune Encephalomyelitis in C57 BL/6 Mice
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