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The 24.2% weight reduction at 48 weeks, combined with improvements in triglycerides, liver enzymes, and insulin sensitivity markers, positions Retatrutide as the more mechanistically complete compound in the Retatrutide vs Tirzepatide framework, pending Phase 3 confirmation

[79] emphasizes tirzepatide's potential benefits through a meta-analysis of large randomized clinical trials, in vitro tests employing human cardiac AC16 cells in high glucose settings, and detailed bioinformatics analyses

M., & Scavone, C