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This complex process means that conditions affecting the stomach or intestines can significantly impair B12 absorption, including pernicious anaemia, atrophic gastritis, previous gastric surgery, coeliac disease, Crohn's disease, and long-term use of certain medications (such as metformin, proton pump inhibitors, and H2 antagonists)

Kolovrat et al., 2020) rapidly activating alternative bypassing pathways to adequately reestablish the blood flow (Vukojevic et al., 2018

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