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Mol Neurobiol 61 , 15071526 (2024)

Deficiency does not cause clinical depression by itself, but it contributes to a flatness or low-grade sadness that does not respond well to lifestyle changes alone

They're tools that make caloric restriction easier to sustain, not replacements for healthy habits

By potentially reducing the presence and impact of senescent cells, FOXO4-DRI might thereby restore tissue homeostasis and reduce biomarkers of cell aging