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Residence time is defined by the rate of dissociation from the receptor (1/ k off ), so we used time-resolved Forster resonance energy transfer (TR-FRET) to measure agonist-binding kinetics in CHO-SNAP-GLP-1R cells
Future prospective studies could better adjust for such confounders
Nov 2006;91(11):1506-1512
It targets a different two-receptor combination than tirzepatide (glucagon instead of GIP), which gives it unique metabolic benefits, particularly for liver fat
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