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In another in vitro and in vivo study, Nrf2/HO-1 was also demonstrated to play an important inhibitory role in the pro-fibrotic pathway activated by TGF-1, which was verified by oligo-fucoidan in NRK-52E cells and kidney tissues of C57BL/6 mice [151]
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However, this was not sufficient to rescue the decreased lipogenic factors or decreased circulating triglycerides (Fig
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