novo retatrutide ADA: CSO says 'jury still out' on CagriSema v. Weight loss drug retatrutide use

The favorable community experience provides context but cannot definitively answer the cancer safety question that only proper long-term human studies could address

Although the cardioprotective effects of GLP-1RA are more established in atherosclerotic cardiovascular disease than in heart failure, recent studies demonstrate a modest but clinically meaningful benefit in heart failure with preserved ejection fraction (HFpEF), particularly among obese patients

Notably, the combination of autophagy inhibitors (such as chloroquine) and ferroptosis inducers (such as erastin) can significantly inhibit breast cancer proliferation, suggesting the potential of synergistic therapy for dual death pathways [114]

If it holds, the right end of this chart could look very different a year from now