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Administration was performed through oral gavage (14, 21, 23, 24), intraperitoneal injection (20), or drinking water (22), and reproductive outcomes were evaluated by histology, morphometric analysis of seminiferous tubules, sperm assessment, and hormone profiling
Clinical trials for retatrutide are designed with rigorous safety monitoring protocols to detect both short- and long-term adverse effects
The impact of long-term effects is not studied yet
I would caution patients who already have a diagnosis of gastroparesis not to use this medication and make all patients aware of this
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