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This selectivity is the compounds primary research utility: it allows investigators to study IRR-mediated signaling in isolation, without the confounding receptor crosstalk associated with full-length erythropoietin in cell-based assay systems
For example, at the cellular level, primary neuronal cells from GLP-1R KO and WT mice could be cultured, and the levels of cAMP and changes in downstream phosphorylation of PKA and CREB signaling pathway after GLP-1R agonist treatment could be tested
Their activation may alter inflammatory responses and cellular processes within the skin
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